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RE: Router: No route is known from this host to the destination address ~Bella Kiresatherjip 29.May.03 07:03 PM a Web browser Domino Server All ReleasesAll Platforms
I'm no expert on networking but it sounds to me like your ISP is blocking you by mistake.
If you can't telnet on port 25 from within your organization to the mail server of the company down the street, then Domino will not be able to send mail there either.